Athlete's Foot Research Today is a free monthly online journal that collates and summarizes the latest research about Athlete's Foot, including details on tinea, causes, treatment, prevention. | ||||||||
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Successful treatment of laryngeal stenosis in laryngo-onycho-cutaneous syndrome with topical mitomycin C.Phillips PS, Amonoo-Kuofi K, Hore ID, Atherton DJ, Albert DM Department of Pediatric ENT, Great Ormond Street Hospital for Children, London, United Kingdom. seamusphillips@hotmail.com Laryngo-onycho-cutaneous syndrome is a very rare entity found in Punjabi families. It affects the skin, nails, and larynx. Laryngeal involvement may cause lethal airway obstruction, and has in the past proved very difficult to treat. Mitomycin C is an antibiotic that acts as an alkylating agent, inhibiting DNA synthesis. It reduces fibroblast proliferation, and has previously been used to treat choanal atresia and laryngeal stenosis. We report an 18-year-old man with complete transglottic laryngeal stenosis secondary to laryngo-onycho-cutaneous syndrome. An airway was established by dissection with a bougie and sickle knife, and was initially maintained by the upper limb of a Montgomery T-tube. Laryngeal granulation tissue present on removal of the T-tube was treated with topical mitomycin C (2 mg/mL) applied for 4 minutes on two occasions with an interval of 1 month. A year later, the airway remained patent, with no granulation tissue. Published 31 January 2006 in Pediatr Dermatol, 23(1): 75-7.
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